If you are trying to create highly available file systems, especially across data centers, then ChironFS is one potential solution. It's relatively new, so there aren't lots of experience reports, but it looks worth considering. What is ChironFS and how does it work?
Adapted from the ChironFS website:
The Chiron Filesystem is a Fuse based filesystem that frees you from single points of failure. It's main purpose is to guarantee filesystem availability using replication. But it isn't a RAID implementation. RAID replicates DEVICES not FILESYSTEMS.
Why not just use RAID over some network block device? Because it is a block device and if one server mounts that device in RW mode, no other server will be able to mount it in RW mode. Any real network may have many servers and offer a variety of services. Keeping everything running can become a real nightmare!