Other than StackOverflow, PlentyOfFish is perhaps the most spectacular example of scale-up architectures working for what your average sane person would consider a large system. It doesn't hurt that it's also a sexy story.
Update 5: PlentyOfFish Update - 6 Billion Pageviews And 32 Billion Images A Month
Update 4: Jeff Atwood costs out Markus' scale up approach against a scale out approach and finds scale up wanting. The discussion in the comments is as interesting as the article. My guess is Markus doesn't want to rewrite his software to work across a scale out cluster so even if it's more expensive scale up works better for his needs.
Update 3: POF now has 200 million images and serves 10,000 images served per second. They'll be moving to a 250,000 IOPS RamSan to handle the load. Also upgraded to a core database machine with 512 GB of RAM, 32 CPU’s, SQLServer 2008 and Windows 2008.
Update 2: This seems to be a POF Peer1 love fest infomercial. It's pretty content free, but the production values are high. Lots of quirky sounds and fish swimming on the screen.
Update: by Facebook standards Read/WriteWeb says POF is worth a cool one billion dollars. It helps to talk like Dr. Evil when saying it out loud.
PlentyOfFish is a hugely popular on-line dating system slammed by over 45 million visitors a month and 30+ million hits a day (500 - 600 pages per second). But that's not the most interesting part of the story. All this is handled by one person, using a handful of servers, working a few hours a day, while making $6 million a year from Google ads. Jealous? I know I am. How are all these love connections made using so few resources?