Skype uses PostgreSQL as their backend database. PostgreSQL doesn't get enough run in the database world so I was excited to see how PostgreSQL is used "as the main DB for most of [Skype's] business needs." Their approach is to use a traditional stored procedure interface for accessing data and on top of that layer proxy servers which hash SQL requests to a set of database servers that actually carry out queries. The result is a horizontally partitioned system that they think will scale to handle 1 billion users.