This is what Mike Peters says he can do: make your site run 10 times faster. His test bed is "half a dozen servers parsing 200,000 pages per hour over 40 IP addresses, 24 hours a day." Before optimization CPU spiked to 90% with 50 concurrent connections. After optimization each machine "was effectively handling 500 concurrent connections per second with CPU at 8% and no degradation in performance."
Mike identifies six major bottlenecks:
Find more details in Mike's article.